Fmoc-Amino Acids Attached to Wang Resins

 

Fmoc-amino acid Wang resins are used for the Fmoc solid phase synthesis of peptide acids. The resins consist of 1% cross-linked polystyrene beads which have been functionized with the TFA labile p-benzyloxybenzyl alcohol linker. All following Fmoc-amino acid Wang resins are prepared by the method of Sieber [1], which gives less enatiomerization and dipeptide formation than those generated by using conventional DCC/DMAP method. The substitution rate of amino acid on resin is determined by photometric measuring the Fmoc-chromophore liberated upon treatment with piperidine/DMF.

[1] P. Sieber, Tetrahedron Lett., 1987, 28, 6147

 

10011

Na -(9-Fluorenylmethoxycarbonyl)-L-alanine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$20

$80

$320

 

10012

Na -(9-Fluorenylmethoxycarbonyl)-D-alanine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$60

$245

$980

10021

Na-(9-Fluorenylmethoxycarbonyl)-Ng -(2,2,4,6,7)-

pentamethyl-dihydro-benzofuran-5-sulfonyl)-

L-arginine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh

as specified

1 g

5 g

25 g

$70

$270

$1,100

 

10022

Na-(9-Fluorenylmethoxycarbonyl)-Ng -(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-

D-arginine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$135

$540

$2,160

10023

Na-(9-Fluorenylmethoxycarbonyl)-Ng -4-methoxy-

2,3,6-trimethyl-benzenesulfonyl-L-arginine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$95

$380

$1,520

 

10024

Na-(9-Fluorenylmethoxycarbonyl)-Ng -4-methoxy-

2,3,6-trimethyl-benzenesulfonyl-D-arginine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$135

$540

$2,160

 

10031

Na-(9-Fluorenylmethoxycarbonyl)-Nb -trityl-

L-asparagine p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$45

$175

$700

 

10032

Na-(9-Fluorenylmethoxycarbonyl)-Nb -trityl-

D-asparagine p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10041

Na-(9-Fluorenylmethoxycarbonyl)-b -(t-butyl ester)-

L-aspartic acid p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$35

$140

$560

 

10042

Na-(9-Fluorenylmethoxycarbonyl)-b -(t-butyl ester)-

D-aspartic acid p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10051

Na-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$60

$240

$960

 

10052

Na-(9-Fluorenylmethoxycarbonyl)-S-trityl-D-cysteine

p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$150

$590

$2,360

 

10053

Na-(9-Fluorenylmethoxycarbonyl)-S-acetamido-

methyl-L-cysteine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh

as specified

1 g

5 g

25 g

$45

$175

$700

 

10054

Na-(9-Fluorenylmethoxycarbonyl)-S-acetamido-

methyl-D-cysteine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh

as specified

1 g

5 g

25 g

$150

$590

$2,360

 

10055

Na-(9-Fluorenylmethoxycarbonyl)-S-(t-butyl)-

L-cysteine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$100

$400

$1,600

 

10061

Na-(9-Fluorenylmethoxycarbonyl)-Ng -trityl-

L-glutamine p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$65

$270

$1,080

 

10062

Na-(9-Fluorenylmethoxycarbonyl)-Ng -trityl-

D-glutamine p-benzyloxy-benzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10071

Na-(9-Fluorenylmethoxycarbonyl)-g -(t-butyl ester)-

L-glutamic acid p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$35

$140

$570

 

10072

Na-(9-Fluorenylmethoxycarbonyl)-g -(t-butyl ester)-

D-glutamic acid p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10081

Na-(9-Fluorenylmethoxycarbonyl)-glycine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10091

Na-(9-Fluorenylmethoxycarbonyl)-Nim-trityl-

L-histidine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$60

$240

$960

 

10101

Na-(9-Fluorenylmethoxycarbonyl)-L-isoleucine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10111

Na-(9-Fluorenylmethoxycarbonyl)-L-leucine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10112

Na-(9-Fluorenylmethoxycarbonyl)-D-leucine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$65

$270

$1,080

 

10121

Na-(9-Fluorenylmethoxycarbonyl)-Ne -(t-butyloxy-carbonyl)-L-lysine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$35

$140

$575

 

10122

Na-(9-Fluorenylmethoxycarbonyl)-Ne -(t-butyloxy-carbonyl)-D-lysine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10131

Na-(9-Fluorenylmethoxycarbonyl)-L-methionine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10132

Na-(9-Fluorenylmethoxycarbonyl)-D-methionine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$60

$245

$980

 

10211

Na-(9-Fluorenylmethoxycarbonyl)-L-norleucine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$35

$140

$560

 

10212

Na-(9-Fluorenylmethoxycarbonyl)-D-norleucine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$70

$295

$1,180

 

10141

Na-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10142

Na-(9-Fluorenylmethoxycarbonyl)-D-phenylalanine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$70

$295

$1,180

 

10151

Na-(9-Fluorenylmethoxycarbonyl)-L-proline

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10152

Na-(9-Fluorenylmethoxycarbonyl)-D-proline

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$65

$270

$1,080

 

10163

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

L-serine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$40

$160

$640

 

 

10164

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

D-serine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10173

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

L-threonine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$40

$160

$640

 

10174

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

D-threonine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,940

 

10181

Na-(9-Fluorenylmethoxycarbonyl)-L-tryptophan

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10182

Na-(9-Fluorenylmethoxycarbonyl)-D-tryptophan

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$90

$370

$1,480

 

10183

Na-(9-Fluorenylmethoxycarbonyl)-Nin-

(t-butyloxy-carbonyl)-L-tryptophan

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$80

$320

$1,280

 

10193

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

L-tyrosine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$35

$140

$575

 

10194

Na-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl ether)-

D-tyrosine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$120

$490

$1,960

 

10201

Na-(9-Fluorenylmethoxycarbonyl)-L-valine p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$15

$60

$250

 

10202

Na-(9-Fluorenylmethoxycarbonyl)-L-valine

p-benzyloxybenzyl alcohol resin

Substitution: 0.3 - 0.8 mmole/g resin

Bead size 100 - 200 mesh or 200- 400 mesh as specified

1 g

5 g

25 g

$70

$295

$1,180